Released on 6/13, Alli is the first FDA-approved over-the-counter weight-loss aid. Alli (pronounced "ally" - clever, huh?) helps you lose weight by working in your digestive system (as opposed to your heart or brain) to block fat. The best deal? Drugstore.com has it for $49.25 but new customers can use this link for $5 off $30 or $10 off $50 plus free shipping. Otherwise, Amazon has it for $48.99 plus free shipping. And neither charges sales tax (a few states excluded), which will save you an extra $4 or so over a local store.