This deal has ended.
Amazon now has the Logitech Harmony One Advanced Universal Remote Control on sale for $149.99, the best price available by around $20. It's programmable through your computer via USB, features a full-color touchscreen, and can be used for almost anything including TVs, stereos, DVD players, Tivos, and even things like lighting and ceiling fans. It's received an impressive 4.5 out of 5 stars from over 800 Amazon buyers. Shipping is free and there's no sales tax (except KS, KY, ND, NY, WA).